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Welcome, eCureMe.com medical contents search April 25, 2013
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Acetadote (Acetylcysteine)


Poison and drug dependence


Poisoning/overdose


Hepatic injury after acetaminophen overdose.


Adults & children: give within 8 hours of overdose or ¡Â24 hours if time of overdose is unknown. Loading dose: 150mg/kg IV infusion, given over 60 minutes. Maintenace: 50mg/kg given over 4 hours, then 100mg/kg given over 16 hours.


Category B


Rash, urticaria, facial flushing, itching, edema, tachycardia, hypotension, GI upset


Pregnancy Risk Categories defined:

A: Studies in pregnant women failed to show a risk to the fetus in the first trimester - with no evidence of risk in the later trimesters.

B: Animals studies indicate no adverse effect to the fetus, but there are no adequate, clinical studies in pregnant women.

C: Animal studies have shown an adverse effect on the fetus, but there are no adequate, clinical studies in humans. Despite potential risks, the drug may be useful in pregnant women.

D: There is evidence of risk to the human fetus, but the potential benefits of use in pregnant women may be acceptable, despite potential risks.

X: Studies in animals or humans show fetal abnormalities, or adverse reaction reports indicate evidence of fetal risk. Warning: the risks involved clearly outweigh any potential benefit from using the drug in pregnant women, regardless of trimester.

NR: Not rated (i.e., no information available at this time as to the potential risks or benefits).










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