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Endocrine/Metabolic
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Sex hormone
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(Adults) Acute pain: 200 to 400 mg every 6 to 8 hours as needed. Max 1200 mg/day. Osteoarthritis, Rheumatoid Arthritis: 300 mg 2 or 3 times daily, or 400 or 500 mg 2 times daily. Max 1200 mg/day, take with meal.
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Category C.
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Upset stomach, Diarrhea, abdominal pain, Constipation, nausea, dizziness, headache, rash, Heart Failure, photophobia, melena, peptic ulceration with or without GI bleeding or perforation, renal failure, leukopenia, agranulocytosis, hepatitis, Asthma, Stevens-Johnson syndrome.
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Pregnancy Risk Categories defined:
A: Studies in pregnant women failed to show a risk to the fetus in the first
trimester - with no evidence of risk in the later trimesters.
B: Animals studies indicate no adverse effect to the fetus, but there are no adequate,
clinical studies in pregnant women.
C: Animal studies have shown an adverse effect on the fetus, but there are no adequate,
clinical studies in humans. Despite potential risks, the drug may be useful in pregnant
women.
D: There is evidence of risk to the human fetus, but the potential benefits of use in
pregnant women may be acceptable, despite potential risks.
X: Studies in animals or humans show fetal abnormalities, or adverse reaction reports
indicate evidence of fetal risk. Warning: the risks involved clearly outweigh any
potential benefit from using the drug in pregnant women, regardless of trimester.
NR: Not rated (i.e., no information available at this time as to the potential
risks or benefits).
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