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Thin Basement Membrane Disease
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Thin glomerular basement membrane disease
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- This is a pathologic entity with the finding of blood or protein in the urine
- Transmitted in most cases as an autosomal dominant disease
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- Blood or protein in the urine
- Body swelling
- High blood pressure in more than 35% of cases
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- Association between the disease and COL4A3/COL4A4 genes are conflicting.
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- Urine test shows blood or protein in the urine
- Renal biopsy with electron-microscopic examination shows glomerular basement membrane (BM) thinning.
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- Supportive treatment for
complications:
- Fluid restriction
- Manage hyperkalemia (high potassium)
- Control hypertension
- Dialysis
- Renal transplantation
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- High blood pressure
- Diminished amount of urine
- Chronic renal failure
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- This usually has a good prognosis.
- Glomerular sclerosis in the initial biopsy suggests a progressive disease.
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