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Clonorchiasis

more about Clonorchiasis


Chinese liver fluke or Opisthorchiasis

  • This is a parasitic worm that occurs throughout Asia and Europe. The worm has a complicated life cycle, which results in human infection. Snails ingest eggs from water contaminated by human or animal feces. The eggs turn into larvae that leave the snails, and then infect fish. The infected fish are then eaten by humans, and cause infection. The infection in humans spreads to the bile ducts (in the liver) and the gallbladder.

  • None in mild infection
  • Initial symptoms
    1. Low-grade fever
    2. Malaise
    3. Joint aches
    4. Hives
    5. Abdominal pain in right or middle upper abdomen
    6. Enlarged, tender liver
  • Chronic Infection
    1. Pain in middle upper abdomen
    2. Low-grade fever
    3. Diarrhea
    4. Right upper abdomen pain
    5. Appetite loss
    6. Weakness
    7. Enlarged liver

  • Eating infected fish

  • Often difficult initially
  • Laboratory:

- Initial phase

    1. Elevated white blood cell count
    2. Increased eosinophil count
    3. Elevated Alanine Aminotransferase
  • Chronic phase:
    1. Eggs found in stool
    2. Eggs in duodenal (intestinal) aspirate
    3. Elevated liver tests in severe infections only
    4. May have elevated white blood cell count
    5. May have increased eosinophils
    6. Elisa blood test (77% sensitive)
  • Imaging
    1. CT scan
    2. Ultrasound
    3. Trans-hepatic cholangiograms (gallbladder test)

  • Praziquantel works in 95% of all cases
  • Mebendazole
  • Albendazol





more about Clonorchiasis


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