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Dilantin (Phenytoin sodium)
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Central nervous system agents
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Analgesics
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Control of generalized Seizures, and prevention and treatment of Seizures occurring during or following neurosurgery.
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(Adults) Initially one 100 mg capsule 3 times daily. Usual maintenance dose 1 capsule3 to 4 times daily. Once-daily dosage of 300 mg/day may be considered. (Children) Initially 5 mg/kg/day in 2 or 3 equally divided doses. Usual maintenance dose 4 to 8mg/kg/day. Max 300 mg/day before or after meal.
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Contraindicated.
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Nystagmus, slurred speech, mental confusion, nausea, vomiting, Constipation, gingival enlargement.
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Pregnancy Risk Categories defined:
A: Studies in pregnant women failed to show a risk to the fetus in the first
trimester - with no evidence of risk in the later trimesters.
B: Animals studies indicate no adverse effect to the fetus, but there are no adequate,
clinical studies in pregnant women.
C: Animal studies have shown an adverse effect on the fetus, but there are no adequate,
clinical studies in humans. Despite potential risks, the drug may be useful in pregnant
women.
D: There is evidence of risk to the human fetus, but the potential benefits of use in
pregnant women may be acceptable, despite potential risks.
X: Studies in animals or humans show fetal abnormalities, or adverse reaction reports
indicate evidence of fetal risk. Warning: the risks involved clearly outweigh any
potential benefit from using the drug in pregnant women, regardless of trimester.
NR: Not rated (i.e., no information available at this time as to the potential
risks or benefits).
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