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Cutaneous T Cell Lymphoma
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Mycosis
fungoides
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- This is a type of Lymphoma (cancer of
the lymph cells) that involves the skin. In most cases, it
is very slow growing (over many years). Risk factors include
exposure to metals, solvents, petrol chemicals, and HTLV-1
infection.
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- Red scaling patches
- Skin ulcers
- Late in the disease the spleen or
liver, or both may enlarge.
- Area affected is usually at least 2
inches
- Lymph gland swelling occurs later in
the disease
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- Skin biopsy
- Sezary cells -- abnormal cells may
be present in the blood
- HTLV-1 blood serology
- Electron microscopy
- Chest X-Ray
- Abdominal CAT
scan
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- Mechlorethamine ointment (nitrogen
mustard)
- Topical corticosteroids
- PUVA (ultraviolet light therapy)
treatment
- REPUVA is retinoids added to PUVA
treatment
- Radiation
- Chemotherapy (Methotrexate) for
advanced disease
- Interferon and Interleukin-2 are two
of the newer forms of therapy.
- Electron beam therapy
- Combination therapy for advance
disease
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