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Cardiovascular agent
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1) Hypertension: Accupril is indicated for the treatment of hypertension. It may be used alone or in combinaiton with thiazide diuretics. (2) Heart Failure: Accupril is indicated in the management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis.
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1) Hypertension: Initial - 10 mg once a day; maximum - 80 mg per day. 2) Congestive Heart Failure - 5-10mg daily; maximum - 20 mg twice daily.
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Category D
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Dry cough, rash, fatigue, dizziness.
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Pregnancy Risk Categories defined:
A: Studies in pregnant women failed to show a risk to the fetus in the first
trimester - with no evidence of risk in the later trimesters.
B: Animals studies indicate no adverse effect to the fetus, but there are no adequate,
clinical studies in pregnant women.
C: Animal studies have shown an adverse effect on the fetus, but there are no adequate,
clinical studies in humans. Despite potential risks, the drug may be useful in pregnant
women.
D: There is evidence of risk to the human fetus, but the potential benefits of use in
pregnant women may be acceptable, despite potential risks.
X: Studies in animals or humans show fetal abnormalities, or adverse reaction reports
indicate evidence of fetal risk. Warning: the risks involved clearly outweigh any
potential benefit from using the drug in pregnant women, regardless of trimester.
NR: Not rated (i.e., no information available at this time as to the potential
risks or benefits).
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